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FDA 21 CFR Part 11 Compliant

Electronic Signatures for Clinical Trials

The secure e-signature platform built for clinical trials, pharmaceuticals, and life sciences. Complete FDA, EU CTR 536/2014, and GDPR compliance with 25-year document retention.

No credit card required
14-day free trial
Validation docs included
certivo.io/documents
Documents
+ New

Clinical Protocol v2.1

PDF

Signed

Delegation Log

PDF

Pending

Site Agreement

PDF

In Progress
ALCOA+ Compliant

Complete audit trail with hash-chain verification

Compliant with global regulatory standards

FDA 21 CFR Part 11USA
EU CTR 536/2014EU
UK MHRA 2026UK
GDPR CompliantEU
EU GMP Annex 11EU

Get Documents Signed in Three Steps

Streamlined workflow designed for regulatory compliance without the complexity

01

Upload Document

Upload your PDF document and add signature fields, initials, dates, and custom form fields.

02

Add Signers

Add recipients with sequential or parallel routing. Set signing order and deadline reminders.

03

Track & Complete

Monitor signing progress in real-time. Download signed documents with complete audit trails.

Enterprise Features

Built for Compliance & Security

Every feature designed to meet the strictest regulatory requirements

FDA 21 CFR Part 11

Complete compliance with validation documentation, IQ/OQ protocols, and configurable controls.

Read our Part 11 guide

ALCOA+ Audit Trails

Immutable hash-chain audit trails capturing who, what, when, where, and why for every action.

Learn about audit trails

25-Year Retention

EU CTR 536/2014 compliant document retention with guaranteed accessibility.

Read our EU CTR guide

Two-Factor Authentication

Enterprise-grade security with TOTP-based 2FA and backup codes.

Platform selection guide

Flexible Workflows

Sequential or parallel signing with automated reminders and deadline management.

E-signatures in clinical trials

Regulatory Exports

One-click compliance packages for FDA, MHRA, or EMA inspections.

GxP compliance guide
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Regulatory Compliance
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Document Retention
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AES Encryption
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Uptime SLA
Global Compliance

Ready for FDA, EU & UK Inspections

The first e-signature platform with built-in compliance for EU Clinical Trial Regulation 536/2014, UK MHRA 2026 requirements, and FDA 21 CFR Part 11.

FDA 21 CFR Part 11 electronic records and signatures
EU CTR 536/2014 Article 58 - 25-year retention
UK MHRA 2026 clinical trial requirements
GDPR Article 30 records of processing activities
EU GMP Annex 11 computerized systems
ALCOA+ data integrity principles

25-Year Retention

EU CTR Article 58 compliant storage

Regulatory Exports

One-click compliance packages

GDPR Records

Article 30 processing activities

Archive Management

Named individual responsibility

Trusted by Regulated Industries

Purpose-built for organizations requiring validated, compliant electronic signature systems

Clinical Research

Informed consent, protocols, site agreements

Pharmaceutical QA

Batch records, SOPs, deviation reports

Medical Devices

Design history files, validation protocols

Laboratory Systems

Test results, method validation, logs

Ready to Go Paperless?

Join clinical sites and pharmaceutical companies using Certivo for FDA-compliant electronic signatures. Start your free trial today.

No credit card required • 14-day free trial • Full validation documentation included

Frequently Asked Questions

FDA 21 CFR Part 11 establishes the criteria for electronic records and electronic signatures to be considered trustworthy, reliable, and equivalent to paper records. Certivo ensures complete compliance with validation documentation, ALCOA+ audit trails, system access controls, unique user identification, and configurable record retention up to 25 years.

EU Clinical Trial Regulation 536/2014 is the European regulatory framework for clinical trials. Article 58 requires sponsors to retain the clinical trial master file for at least 25 years after the trial ends. This ensures long-term safety monitoring and allows regulatory authorities to access complete trial documentation.

ALCOA+ is the data integrity framework required by FDA and EU GMP Annex 11. It stands for Attributable, Legible, Contemporaneous, Original, Accurate, plus Complete, Consistent, Enduring, and Available. Certivo audit trails meet all ALCOA+ requirements.

Certivo one-click regulatory export generates a complete compliance package including full audit trail with hash-chain verification, document access logs, GDPR Article 30 processing records, and retention settings. Exports are available filtered by date range, workflows, or requesting authority (FDA, MHRA, EMA).

Yes! Recipients receive a secure signing link via email and can sign documents without creating an account. All signature events are fully audited with IP address, timestamp, and device information for complete regulatory compliance.

Absolutely. Certivo uses bank-level encryption (TLS 1.3 in transit, AES-256 at rest) with multi-tenant data isolation. All passwords are hashed with bcrypt, and we support two-factor authentication. Documents are verified with SHA-256 hash integrity checks.